903 results found
    1. Biochemistry and Chemical Biology
    2. Medicine

    Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

    Erin G Conlon et al.
    Idiopathic patients along a complex motor neuron disease-dementia spectrum exhibit mRNA splicing changes that are due to multi-protein insolubility.
    1. Cell Biology

    Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking

    Alina Goldstein-Levitin et al.
    Precise hydrogen-bond stabilization of the neck linker docking onto the catalytic motor domain, is crucial for motor activity and intracellular functions of the bi-directional mitotic kinesin-5 Cin8.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome

    Georgia Panagiotakos et al.
    The Timothy syndrome mutation in Cav1.2 gives rise to defects in neuronal differentiation by preventing a developmental switch in channel splicing and elevating calcium signaling in differentiating cells.
  1. June roundup of eLife papers in the news

    Showcasing the top mentions that eLife papers received in June.
  2. city map at night

    Rebuilding foundations: Making Open Knowledge Maps future-proof

    How the Open Knowledge Maps team tackled technical debt, while building the foundations for new promising features.
  3. Travel Grants: The first winners of 2019

    Five women and two men receive the first round of eLife early-career travel awards this year.
    1. Neuroscience

    TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions

    Zhiguo Ma, Marc R Freeman
    Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.
    1. Neuroscience

    Spatial readout of visual looming in the central brain of Drosophila

    Mai M Morimoto et al.
    In the Drosophila central brain, synaptic connectivity extracts visual-spatial information from the axons of looming sensitive LC6 neurons that terminate in a glomerulus with minimal retinotopy.
    1. Developmental Biology

    Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models

    Kyeong-Hye Moon et al.
    Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.

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