241 results found
    1. Developmental Biology
    2. Neuroscience

    Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

    Sonia Q Sen et al.
    Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
    1. Developmental Biology

    aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

    Matthew Robert Hannaford et al.
    The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
    1. Developmental Biology

    Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano

    Magda Grudniewska et al.
    De novo transcriptome assembly and comprehensive characterization of gene expression in proliferating cells of regeneration-capable flatworm Macrostomum lignano advance this organism as a powerful model for stem cell research.
    1. Developmental Biology

    Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

    Sho Ohta et al.
    Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

    Chwee Tat Koe et al.
    A novel complex composed of various components of a chromatin remodeling complex, a chromatin remodeling factor and a transcription factor suppresses the dedifferentiation of intermediate neural progenitors back into neuroblasts in Drosophila.
    1. Developmental Biology

    Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila

    Conor W Sipe, Sarah E Siegrist
    Using Drosophila as a model organism shows that neural stem cell proliferation decisions in response to dietary nutrient conditions can be regulated by cell-autonomous lineage factors.
    1. Neuroscience

    Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

    Mubarak Hussain Syed et al.
    A steroid hormone acts directly on brain neural progenitors to coordinately alter gene expression and specify neuronal and glial cell types.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Developmental Biology
    2. Neuroscience

    Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells

    Young Rae Ji et al.
    Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.

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