A novel and distinct cholecystokinin brain circuit critically modulates food intake and body weight.

Glutamatergic signaling from the lateral hypothalamus instructs lateral habenular neurons for encoding aversive external stimuli to subsequently guide escape behaviours.

A mouse model that grew without functional leptin receptors until adulthood reveals that early defects in leptin signaling lead to permanent metabolic and developmental problems.

Drosophila polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca²⁺ influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.

Drosophila nociceptive neurons convert high-intensity stimuli into characteristic fluctuations of firing rates, quiescent periods of which are regulated by hyperpolarization through small conductance Ca²⁺-activated K⁺ channels.

A rich behavioral data set reveals the complex interactions and influence motivational systems have on one another, driving competition and optimal expression of behavior.

Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.

Encoding an expected, but absent, threat is modulated by dopaminergic neurotransmission that regulates success of extinction learning in humans.

A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.

Calcium response profiling of large populations of enteric neurons reveals hard-wired neural circuits that reflect the motility program portfolio of the intestinal region they occupy.