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Lovastatin fails to improve motor performance and survival in
Claudia Villani et al.
Lovastatin ability to rescue motor deficits and survival in a mouse model of Rett syndrome is strongly influenced by the genetic background.
Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms
Building on previous work (Momeni et al., 2013), it is shown that recognizing the hierarchical organization of biological systems resolves the ongoing controversy on pro-cooperation mechanisms.
Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons
Mohamed Khateb et al.
Primary motor cortex afferents supra-linearly amplify the responses and sharpen angular tuning of neurons in the S1 barrel cortex.
Neuronal sources of
modulate neurogenesis in the adult planarian brain
Ko W Currie et al.
Planarian brain neurons modulate their turnover by signaling to nearby stem cells.
A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis
Yumei Wu et al.
Analysis of neurons that lack the two neuronal dynamins, dynamin 1 and 3, demonstrates a pathway of synaptic vesicle reformation that does not require these two dynamins or clathrin-dependent budding.
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits
Mirko Messa et al.
Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
Stem Cells and Regenerative Medicine
Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells
Yaping Sun et al.
A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
CHIP as a membrane-shuttling proteostasis sensor
Yannick Kopp et al.
The mechanism is revealed that connects the protein degradation machinery to cellular membrane-bound compartments during proteostasis stress in mammalian cells.
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
Sylvie Remaud et al.
Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins
Matthew J Shurtleff et al.
The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
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