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Human Biology and Medicine
Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels
Jerome Robert et al.
Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
Chromosomes and Gene Expression
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
Qin Li et al.
PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
Zhao Xuan et al.
Clarinet, a novel
active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
Sylvie Remaud et al.
Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
CHIP as a membrane-shuttling proteostasis sensor
Yannick Kopp et al.
The mechanism is revealed that connects the protein degradation machinery to cellular membrane-bound compartments during proteostasis stress in mammalian cells.
Dreaming with hippocampal damage
Goffredina Spanò et al.
A provoked awakening protocol during sleep reveals that selective bilateral hippocampal damage in humans is associated with reduced frequency, quality, and content of dreaming.
Corticothalamic phase synchrony and cross-frequency coupling predict human memory formation
Catherine M Sweeney-Reed et al.
Direct electrophysiological evidence demonstrates a role for the anterior thalamic nucleus in human memory formation.
Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms
Building on previous work (Momeni et al., 2013), it is shown that recognizing the hierarchical organization of biological systems resolves the ongoing controversy on pro-cooperation mechanisms.
Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis
Yedidyah Dordek et al.
Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.
YAP controls retinal stem cell DNA replication timing and genomic stability
Pauline Cabochette et al.
The Hippo pathway downstream effector YAP regulates S-phase progression to protect neural stem cells of the retina from experiencing genomic instability.
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