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    1. Genetics and Genomics
    2. Neuroscience

    Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

    Li Hou, Siyuan Guo ... Xianhui Wang
    CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.
    1. Stem Cells and Regenerative Medicine

    Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

    Emily J Lodge, Alice Santambrogio ... Cynthia Lilian Andoniadou
    The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.
    1. Developmental Biology

    The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system

    Sanjay Kumar Sukumar, Vimala Antonydhason ... Ruth H Palmer
    The newly characterized activity regulating neuropeptide encoding gene Spar is a transcriptional target of the Jeb/Alk receptor tyrosine kinase signaling pathway in the Drosophila nervous system.
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal, Asuka Takeishi ... Piali Sengupta
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Neuroscience

    State-dependent activity dynamics of hypothalamic stress effector neurons

    Aoi Ichiyama, Samuel Mestern ... Wataru Inoue
    Hypothalamic stress effector neurons rapidly change activity patterns via recurrent inhibition, representing state-dependent activity switch between baseline and elevated stress levels.
    1. Evolutionary Biology

    Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

    Tianming Wang, Zheng Cao ... Naiming Zhou
    Identification and functional characterization of the first non-chordate kisspeptin neuropeptide system in the sea cucumber indicates the ancient origin of the intracellular signaling and physiological functions of this molecular system.
    1. Developmental Biology
    2. Evolutionary Biology

    An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium

    Bicheng He, Marita Buescher ... Gregor Bucher
    An ancestral apical brain center contributed to the evolution of the insect central complex requiring foxQ2, which is essential for the development of midline structures of the insect brain.
    1. Neuroscience

    Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome

    Anton Miroschnikow, Philipp Schlegel ... Michael J Pankratz
    A parallel neuronal network architecture ensures control of basic feeding reflex circuits via integration of crossmodal sensory information to filter multiple biological events and enhance meaningful behavioral choice.
    1. Cancer Biology

    Molecular classification and tumor microenvironment characteristics in pheochromocytomas

    Sen Qin, Yawei Xu ... Zheng Zhang
    ScRNA-seq of diverse pheochromocytoma patients reveals distinct microenvironment characteristics and supports an informative molecular classification system.
    1. Developmental Biology

    Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation

    Maria R Stupnikov, Ying Yang ... Wellington V Cardoso
    Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.