106 results found
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Neuroscience

    Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

    Irene Bolea et al.
    Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
    1. Neuroscience

    Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

    Julia Patzig et al.
    A newly identified component in the architecture of the axon/myelin-unit – the septin/anillin scaffold – maintains the structure of myelin in the central nervous system, thereby preventing myelin outfoldings.
    1. Neuroscience

    A machine-vision approach for automated pain measurement at millisecond timescales

    Jessica M Jones et al.
    Development of a fully automated pain scale using machine learning tools in computational neuroethology and creation of new software, reveals a robust circuit-dissection compatible platform for objective pain measurement.
    1. Neuroscience

    Neuropathological and transcriptomic characteristics of the aged brain

    Jeremy A Miller et al.
    High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A molecular filter for the cnidarian stinging response

    Keiko Weir et al.
    Cnidarian stinging cells use a specialized voltage-gated calcium channel to integrate distinct sensory signals and selectively trigger a predatory response.
    1. Neuroscience

    Translational control of auditory imprinting and structural plasticity by eIF2α

    Gervasio Batista et al.
    Behavioral pharmacology and molecular biology reveal a translational control mechanism underlying auditory imprinting and structural plasticity that can be pharmacologically manipulated to reopen the critical period.
  1. Living Science: Uniting the nations of science

    Eve Marder
    As the world becomes smaller and more uniform, it is important to remember that creativity in science can happen anywhere.
  2. Living Science: Lost voices

    Eve Marder
    When a scientist dies too early in their career we miss them as a colleague and as a person and, as Eve Marder explains, we also lose the science they would have done.

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