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HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
Peng Zhong et al.
HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.
Synergy between loss of
and overexpression of
in neuroblastoma is mediated by the GAP-related domain
Shuning He et al.
A zebrafish model of neuroblastoma reveals that the tumor suppressor NF1 uses different mechanisms to suppress malignant transformation and to down-modulate normal neural crest cell growth during embryogenesis.
Regulation of localization and function of the transcriptional co-activator YAP by angiomotin
Susana Moleirinho et al.
Phosphorylation of Angiomotin regulates YAP localization and activity.
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
Jiandong Sun et al.
A new mechanism linking lysosomes to mTOR regulation and synaptic plasticity involves p18 ubiquitination by Ube3a, and underlies some of the pathology observed in Angelman syndrome.
Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex
Lei Xing et al.
Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
Biochemistry and Chemical Biology
Computational and Systems Biology
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution
Scott M Coyle, Wendell A Lim
A systems level reconstitution of H-Ras GTPase signaling reveals a rich space of tunable dynamic outputs and clarifies the consequences of oncogenic perturbations to signaling.
Pak1 kinase controls cell shape through ribonucleoprotein granules
Joseph O Magliozzi, James B Moseley
A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
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