During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
Hirofumi Noguchi, Jessica Chelsea Arela ... Samuel Pleasure
Hilar mossy cells control seizure-dependent dentate neurogenesis and stem cell quiescence by activity-dependent control of Sonic hedgehog production and signaling.
Kerstin Hasenpusch-Theil, Christine Laclef ... Thomas Theil
Primary-cilia-mediated processing of the Gli3 transcription factor enables the formation of subtypes of projection neurons in appropriate numbers during the development of the cerebral cortex.
The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
Stephen Johnston, Sarah L Parylak ... Matthew Shtrahman
Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
Control of neural stem cells by reactive oxygen species (ROS) provides a link between systemic shifts in oxygen tension and neuronal regeneration, and suggests an evolutionary driving force for the inherent ability of newts to regenerate their brain cells.