157 results found
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Neuroscience

    High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

    Jian Qiu et al.
    Kisspeptin neurons in the hypothalamus release peptide and amino acid neurotransmitters that work together to coordinate the activity of gonadotropin-releasing hormone neurons and subsequent release of reproductive hormones.
    1. Neuroscience

    NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

    Chrysanthi Fergani et al.
    Kiss1 neurons and NKB-responsive neurons of the medial amygdala stimulate LH release in females through different (previously unknown) pathways which, in the case of NKB-responsive neurons, are kisspeptin-independent but estradiol-dependent.
    1. Neuroscience

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

    Silvia Leon et al.
    The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
    1. Neuroscience

    Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

    Xinhuai Liu et al.
    The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of gonadotropin-releasing hormone.
    1. Neuroscience

    Luqin-like RYamide peptides regulate food-evoked responses in C. elegans

    Hayao Ohno et al.
    Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
    1. Developmental Biology
    2. Evolutionary Biology

    Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer

    Iryna Kozmikova, Zbynek Kozmik
    Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.
    1. Developmental Biology
    2. Evolutionary Biology

    Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

    Astrid Deryckere et al.
    Neurogenic progenitor cells surrounding the eye placode generate neurons that migrate over long distances to the developing octopus brain.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Translational control of nociception via 4E-binding protein 1

    Arkady Khoutorsky et al.
    The mTOR downstream effector eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) regulates mechanical nociception via translational control of synaptic transmission in the spinal cord.
    1. Cell Biology
    2. Neuroscience

    Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

    Guanglin Xing et al.
    Neurexin–Neuroligin1 complex positively regulates F-actin assembly through direct interaction with WAVE complex to control normal synaptic growth and electrophysiological function in Drosophila neuromuscular junction.

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