1,145 results found
    1. Developmental Biology
    2. Neuroscience

    Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

    Emily Ling-Lin Pai et al.
    Maf and Mafb differentially regulate MGE-derived cortical and hippocampal interneuron subtype and regional fate in part through promoting the expression of Mef2c and Pnoc during mouse embryonic neurogenesis.
    1. Epidemiology and Global Health

    The global burden of yellow fever

    Katy AM Gaythorpe et al.
    Yellow fever, a potentially deadly viral hemorrhagic fever, causes up to 82,000 deaths annually worldwide, and mass vaccination activities have reduced the burden by 47% in Africa.
    1. Epidemiology and Global Health

    The effect of climate change on yellow fever disease burden in Africa

    Katy AM Gaythorpe et al.
    Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.
    1. Neuroscience

    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

    Poh Hui Chia et al.
    A biallelic missense mutation in the highly conserved, neuron-specific kinase CAMK2A abrogates holoenzyme assembly and causes a new inherited neurodevelopmental disease.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    eIF2B activator prevents neurological defects caused by a chronic integrated stress response

    Yao Liang Wong et al.
    Boosting the function of translation factor eIF2B by chronic small molecule administration prevents pathology in a neurodegenerative model of Vanishing White Matter disease characterized by a maladaptive stress response.
    1. Microbiology and Infectious Disease

    The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

    D Garrett Brown et al.
    Immune stimulation from the microbiota prevents neurological damage associated with viral infection of the central nervous system.
    1. Neuroscience

    Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy

    Wu Chen et al.
    Two genetically distinct Stxbp1 haploinsufficiency mouse models exhibit seizures and impairments in cognitive, psychiatric, and motor functions, representing robust preclinical models of STXBP1 encephalopathy with both construct and face validity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova et al.
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

    Kazi Rahman et al.
    A disease-associated polymorphism in a related protein that regulates neurotransmitter release reveals that antiviral protein IFITM3 forms oligomers to rigidify membranes and inhibit virus fusion with cells.
    1. Neuroscience

    Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses

    Gordon X Wang et al.
    The development of a novel, high throughput method for the sub-synaptic analysis of protein localization in molecularly classified synapse classes allows sub-compartment, multiplexed detection of proteins in synapses using wide-field microscopes.

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