142 results found
    1. Neuroscience

    Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

    Zuzanna Brzosko et al.
    Sequential neuromodulation by acetylcholine and dopamine enables correlational synaptic learning which, when incorporated into a computational model, yields effective navigation toward changing reward locations as in natural foraging behavior.
    1. Neuroscience

    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

    Niklas Byczkowicz et al.
    The cAMP-HCN pathway can control action potential conduction velocity providing neuromodulators with the ability to tune energy consumption and temporal delays across axons in the brain.
    1. Neuroscience

    Synaptic transmission parallels neuromodulation in a central food-intake circuit

    Philipp Schlegel et al.
    Connectomic analysis demonstrates that a brain circuit, that may be conserved between flies and mammals, uses both fast synaptic transmission as well as peptidergic neuromodulation to connect chemosensory and endocrine systems.
    1. Neuroscience

    Neuromodulation of excitatory synaptogenesis in striatal development

    Yevgenia Kozorovitskiy et al.
    Protein kinase A regulates the rapid, activity-dependent genesis of excitatory synapses during striatal development.
    1. Neuroscience

    Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

    Patrick D Ganzer et al.
    Precisely-timed bursts of closed-loop vagus nerve stimulation during rehabilitation restore neural connectivity and substantially improve recovery of motor function after SCI.
    1. Neuroscience

    Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels

    Kara E Zang et al.
    Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
    1. Neuroscience

    An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

    Yu Shen et al.
    The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.
    1. Neuroscience

    Cellular and neurochemical basis of sleep stages in the thalamocortical network

    Giri P Krishnan et al.
    A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.
    1. Neuroscience

    RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

    Brooks G Robinson et al.
    Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
    1. Neuroscience

    Dopamine maintains network synchrony via direct modulation of gap junctions in the crustacean cardiac ganglion

    Brian J Lane et al.
    Dopamine is able to ensure that neural networks maintain critical features of their output, such as synchrony of neuron firing, by directly increasing coupling strength to ensure robust output is maintained.

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