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    1. Computational and Systems Biology
    2. Neuroscience

    Mapping circuit dynamics during function and dysfunction

    Srinivas Gorur-Shandilya, Elizabeth M Cronin ... Eve Marder
    Mapping spike patterns from a small identified circuit reveals the diversity and complexity of circuit dynamics across animals and in response to perturbations.
    1. Neuroscience

    Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

    Stijn A Nuiten, Jan Willem de Gee ... Simon van Gaal
    Pharmacologically elevated catecholamine levels and spatial attention jointly shape perceptual decision-making, revealed by unique, similar, and interactive effects on behavior, drift diffusion modeling parameters, and electrophysiology.
    1. Neuroscience

    Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance

    Su Z Hong, Shiyong Huang ... Alfredo Kirkwood
    Neuromodulation of the expression of Hebbian plasticity enables rapid cortical sensory-induced remodeling in post-critical period adults, and can rescue deficits induced by prolonged sensory deprivation.
    1. Neuroscience

    A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

    Shankar Ramachandran, Navonil Banerjee ... Michael M Francis
    Investigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the previously uncharacterized CKR-1 GPCR.
    1. Neuroscience

    The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

    Hui Zhang, Haifang Wang ... Jie He
    Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.
    1. Neuroscience

    Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

    Filip Sobczak, Patricia Pais-Roldán ... Xin Yu
    The variability of the pupil–fMRI relationship was characterized through a combination of clustering and prediction methods, which revealed brain state-specific subcortical and neuromodulatory activation patterns reflected in pupil dynamics.
    1. Neuroscience

    A neural circuit for flexible control of persistent behavioral states

    Ni Ji, Gurrein K Madan ... Steven W Flavell
    Circuit-wide calcium imaging during C. elegans foraging elucidates the functional architecture of a neural circuit controlling the choice between two alternative behavioral states.
    1. Neuroscience

    Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

    Nathan A Baertsch, Jan-Marino Ramirez
    The neuromodulator substance P enhances mechanisms of recurrent excitation between breaths to control breathing frequency and stability.
    1. Neuroscience

    Emotional vocalizations alter behaviors and neurochemical release into the amygdala

    Zahra Ghasemahmad, Aaron Mrvelj ... Jeffrey J Wenstrup
    The modulatory neurochemicals acetylcholine and dopamine are released differentially into the basolateral amygdala depending on the emotional content of vocalizations and the sex, hormonal state, and experience of listening animals.
    1. Genetics and Genomics
    2. Neuroscience

    Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

    Elias Scheer, Cornelia I Bargmann
    A long-term arousal state is linked to the acute decision to leave a food patch by sensory neurons that integrate neuromodulatory information, food intake, and environmental signals.