5,137 results found
    1. Neuroscience

    Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb

    Shawn D Burton, Nathaniel N Urban
    Fast network oscillations in the mammalian main olfactory bulb emerge from the dense synchronization of gamma-frequency firing among resonant tufted cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Evolving interpretable plasticity for spiking networks

    Jakob Jordan et al.
    Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.
    1. Cell Biology

    Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation

    Hiroko Katsuno-Kambe et al.
    Integrin- and ERK signaling stimulates mammary epithelial cell proliferation when extracellular collagen condenses, causing asymmetric growth of multicellular aggregates that is necessary for elongation during branching morphogenesis.
    1. Cell Biology
    2. Neuroscience

    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

    Shahzad S Khan et al.
    Striatal cholinergic interneurons and astrocytes lose cilia and show dysregulation of Hedgehog signaling in mice with a Parkinson's disease-associated, G2019S LRRK2 mutation or upon loss of PPM1H phosphatase specific for LRRK2-phosphorylated Rab GTPases.
    1. Cancer Biology
    2. Cell Biology

    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

    Tomasz Radaszkiewicz et al.
    RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
    1. Neuroscience

    Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex

    Timothy T Rogers et al.
    Signals recorded directly from human anterior temporal cortex reveal that the brain represents animacy information using a distributed code that changes radically as a stimulus is processed, as predicted by an artificial neural network model.
    1. Cell Biology
    2. Developmental Biology

    Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

    Maureen C Lamb et al.
    Collectively migrating cells control their stiffness by Fascin-dependent control of Myosin activity, and this migratory cell stiffness regulates Myosin activity and stiffness within the cellular substrate to ultimately promote migration.
    1. Neuroscience

    NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

    Theresa Pohlkamp et al.
    Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.
    1. Plant Biology

    A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis

    Kangmei Zhao et al.
    A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
    1. Neuroscience

    Connectomes: Mapping the fly’s ‘brain in the brain’

    Stanley Heinze
    Studying neurons and their connections in the central complex of the fruit fly reveals new insights into how their structure and function shape perception and behavior.
    Insight
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