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    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

    Madeline G Andrews et al.
    mTOR signaling regulates the morphology of a human-enriched neural stem cell population and thus contributes to the radial architecture of the developing human cortex with implications for neurodevelopmental disease.
    1. Developmental Biology
    2. Genetics and Genomics

    Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

    Mingi Hong et al.
    A combination of window-of-sensitivity, genetic, and in vitro findings illuminate mechanisms of gene–environment interaction in a multifactorial model of a common birth defect.
    1. Developmental Biology

    Regulation of dynamic pigment cell states at single-cell resolution

    Margherita Perillo et al.
    Multimodal technologies and the experimental tractability of sea urchin embryos reveal diverse regulatory mechanisms and unique genes for distinct pigment cell states.
    1. Neuroscience

    Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory

    David Levitan et al.
    Stk11 and Fos expression plays an important role in CTA long-term memory formation by modulating the intrinsic excitability of BLApn.
    1. Developmental Biology
    2. Neuroscience

    Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6

    Nathalie Coré et al.
    Vax1 suppresses dopaminergic neuron phenotype by inhibiting Pax6 expression in the subventricular zone of the lateral ventricle and is necessary to generate Calbindin interneurons for the postnatal olfactory bulb.
    1. Developmental Biology
    2. Medicine

    RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

    Md Rakibul Hasan et al.
    RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
    1. Neuroscience

    Temporal selectivity declines in the aging human auditory cortex

    Julia Erb et al.
    The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.
    1. Developmental Biology

    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

    Saishu Yoshida et al.
    DYRK2 regulator governs the mammalian ciliogenesis to maintain proper embryogenesis via activation of the Hh signaling during development in vivo.
    1. Neuroscience

    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

    Genjiro Suzuki et al.
    One α-synuclein strain inhibited proteasome activity and induced apparent pathologies, while the other did not, indicating a strain-dependent toxicity of α-synuclein aggregates, which support a prion-like behavior of α-synuclein.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor

    Nami Kitajima et al.
    Hybrid-type fluorescent ATP sensor showing submicromolar affinity, a large fluorescence response, high selectivity and pH-independence visualized extracellular ATP dynamics in the brain of living mice with high spatiotemporal resolution.