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    1. Neuroscience

    Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation in Drosophila

    Ourania Semelidou, Summer F Acevedo, Efthimios MC Skoulakis
    Habituation to brief olfactory stimulation is biphasic and mediated by distinct neuronal circuits where an initial latency phase is rapidly followed by stimulus devaluation signifying behavioral habituation in Drosophila.
    1. Developmental Biology
    2. Genetics and Genomics

    Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans

    Todd A Starich, Xiaofei Bai, David Greenstein
    Malonyl-CoA, the rate-limiting substrate for fatty acid synthesis, is produced in the soma and delivered through gap junctions to the germline to promote reproduction and coordinate it with nutritional status.
    1. Neuroscience

    Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism

    Susan Lin, Aravind R Gade ... Geoffrey S Pitt
    Variants in FGF13, associated with developmental and epileptic encephalopathies, alter neuronal excitability by affecting inhibitory neurons and by a sodium channel-independent mechanism.
    1. Neuroscience

    Distributed functions of prefrontal and parietal cortices during sequential categorical decisions

    Yang Zhou, Matthew C Rosen ... David J Freedman
    Prefrontal cortex plays a leading role in sequential decisions compared to posterior parietal cortex and relies on nonlinear integration of sensory and mnemonic information for decision formation.
    1. Neuroscience

    Neural circuitry coordinating male copulation

    Hania J Pavlou, Andrew C Lin ... Stephen F Goodwin
    A circuit consisting of motor neurons, inhibitory interneurons and mechanosensory neurons controls copulatory behaviour in male fruit flies.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor, Gregory D Marquart ... Harold A Burgess
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Cell Biology
    2. Neuroscience

    MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

    Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
    MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
    1. Cell Biology
    2. Neuroscience

    Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

    Kirby M Donnelly, Olivia R DeLorenzo ... Margaret M Panning Pearce
    Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
    1. Developmental Biology

    The Drosophila EGF domain protein Uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch

    Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Long-range projection neurons in the taste circuit of Drosophila

    Heesoo Kim, Colleen Kirkhart, Kristin Scott
    Taste pathways to higher brain are critical for learned responses to taste compounds.