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    1. Cell Biology

    A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes

    Claudio Andrés Carril Pardo, Laura Massoz ... Isabelle Manfroid
    Most regenerated cells after β-cell damage in zebrafish are Insulin+ Somatostatin+ bihormonal cells that are functional and able to restore glucose control.
    1. Neuroscience

    Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron

    Xiaonan Zhang, Kaylynn Coates ... Quentin Gaudry
    The activity of serotonergic neurons spanning multiple olfactory areas is regulated by both local synaptic interactions and dendrite wide computations.
    1. Developmental Biology

    TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

    Louise A Stephen, Hasan Tawamie ... Hanno J Bolz
    Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.
    1. Cell Biology
    2. Neuroscience

    Protein composition of axonal dopamine release sites in the striatum

    Lauren Kershberg, Aditi Banerjee, Pascal S Kaeser
    Proximity proteomics combined with mouse genetics are used to assess the composition of active zone-like sites for dopamine release and reveal that the scaffolding protein RIM organizes these sites.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromatin accessibility dynamics across C. elegans development and ageing

    Jürgen Jänes, Yan Dong ... Julie Ahringer
    Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

    Svenja de Buhr, Frauke Gräter
    The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.
    1. Neuroscience

    Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes

    Yelyzaveta Bessonova, Baranidharan Raman
    Electrophysiological and behavioral analyses of odor-evoked responses in the locust olfactory system reveal how serotonin uniformly modifies spontaneous and odor-evoked neural activity and yet drive odor-specific changes in behavioral outcomes.
    1. Developmental Biology
    2. Neuroscience

    Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier

    Jayanarayanan Sadanandan, Sithara Thomas ... Peeyush Kumar T
    Histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control endothelial gene expression for BBB development and prevented Wnt/β-catenin target genes from being expressed in adult CNS ECs.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex

    Sarah K Bowman, Aimee M Deaton ... Welcome Bender
    Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A molecular filter for the cnidarian stinging response

    Keiko Weir, Christophe Dupre ... Nicholas W Bellono
    Cnidarian stinging cells use a specialized voltage-gated calcium channel to integrate distinct sensory signals and selectively trigger a predatory response.