Increased excitation and decreased inhibition associated with abnormal neuronal morphology, aberrant ion channel properties, and synaptic dysfunction contribute to hyperexcitability in Alzheimer’s disease hiPSC-derived neuronal cultures and cerebral organoids.
Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
Dynamic SILAC labeling in combination with mass spectrometry revealed substantial regulation of protein synthesis, degradation, turnover, and abundance during homeostatic scaling in neurons.
Sufu controls dentate gyrus stem cell quiescence by acting as a positive regulator of Shh signaling and loss of Sufu leads to dramatic failure to produce sufficient quiescent stem cells.
The smoking cessation drug varenicline (Chantix) and other weak base ligands reduce a4b2-type nicotinic receptor (a4b2R) upregulation through slow intracellular release due to selective trapping in acidic vesicles that contain a4b2Rs.
Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
Experience strengthens hunting in larval zebrafish by recruiting the forebrain to increase the prey-evoked activity in visual areas and trigger motor activity and prey capture.
Viral transduction and gene manipulation of adult human brain slices will be of great value allowing investigations including therapeutic screening, electrophysiological and structural studies of properties of human CNS circuitry.
Neural computations necessary for efficient control of saccades capture the phenomenon of saccadic suppression, which suggests that neural resources are shared for perception and control.
