1,383 results found
    1. Cell Biology
    2. Developmental Biology

    circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

    Anne Kruse Hollensen et al.
    A neuron-specific circular RNA keeps neuronal differentiation in check by lowering transcription rates from key neuronal marker genes.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng et al.
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
    1. Cell Biology
    2. Developmental Biology

    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

    Xiaochen Fan et al.
    Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

    Anthony J Linares et al.
    The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Developmental Biology
    2. Neuroscience

    Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

    Shalini Singh et al.
    Neuronal progenitor cells autonomously inhibit polarization via the transcription factor Zeb1.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

    Vladislava Chalei et al.
    Dali regulates transcription of the Pou3f3 locus locally and binds and regulates active promoters in trans by modulating DNA methylation status.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome

    Georgia Panagiotakos et al.
    The Timothy syndrome mutation in Cav1.2 gives rise to defects in neuronal differentiation by preventing a developmental switch in channel splicing and elevating calcium signaling in differentiating cells.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo

    Gabriel N Aughey et al.
    A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.

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