3,915 results found
    1. Neuroscience

    Human VMPFC encodes early signatures of confidence in perceptual decisions

    Sabina Gherman, Marios G. Philiastides
    Simultaneous EEG-fMRI reveals neural representations of decision confidence unfolding prior to explicit perceptual choices, in a region of the ventromedial prefrontal cortex typically linked to reward processing and value-based decisions.
    1. Cell Biology

    Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

    Gian-Luca McLelland, Thomas Goiran ... Edward A Fon
    A crucial step during the mitophagy cascade involves the disassembly of connections between mitochondria and the endoplasmic reticulum via the retrotranslocation of Mfn2 tethering complexes by the Parkinson's disease genes PARKIN and PINK1, as well as the ATPase VCP/p97.
    1. Developmental Biology
    2. Genetics and Genomics

    Caspar specifies primordial germ cell count and identity in Drosophila melanogaster

    Subhradip Das, Sushmitha Hegde ... Girish S Ratnaparkhi
    During Drosophila primordial germ cells (PGCs) specification, the centrosome and germplasm are subject to regulation, during the maternal zygotic transition, by Caspar/TER94-dependent degradative pathways that influence PGC determinants.
    1. Computational and Systems Biology
    2. Neuroscience

    Shared and modality-specific brain regions that mediate auditory and visual word comprehension

    Anne Keitel, Joachim Gross, Christoph Kayser
    The comprehension of acoustic and visual speech depends on modality-specific pathways in the brain, which explains why auditory speech abilities and lip reading are not associated in typical adults.
    1. Chromosomes and Gene Expression

    Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

    Mélanie Criqui, Aditi Qamra ... Lea Harrington
    Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.
    1. Cell Biology
    2. Neuroscience

    A scalable and modular automated pipeline for stitching of large electron microscopy datasets

    Gayathri Mahalingam, Russel Torres ... Nuno Macarico da Costa
    A novel image processing infrastructure that is capable of processing petascale datasets and can operate on both electron and light microscopy data.
    1. Neuroscience

    Uncertainty-based inference of a common cause for body ownership

    Marie Chancel, H Henrik Ehrsson, Wei Ji Ma
    Behavioral and computational results show that the perception of our body as our own depends on Bayesian probabilistic reasoning that take into account the variations in sensory uncertainty when integrating visual and somatosensory cues.
    1. Cell Biology
    2. Developmental Biology

    Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules

    Victoria G Castiglioni, Helena R Pires ... Mike Boxem
    PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.
    1. Neuroscience

    Perception of microstimulation frequency in human somatosensory cortex

    Christopher L Hughes, Sharlene N Flesher ... Robert A Gaunt
    Increasing microstimulation frequency in some regions of the human somatosensory cortex decreased the perceived intensity and evoked specific percepts, providing insight into cortical organization and sensory feedback approaches for brain–computer interfaces.
    1. Cell Biology

    Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila

    Johanna Lattner, Weihua Leng ... David Flores-Benitez
    The polarity protein crumbs controls apical secretion and the architecture of the apical domain by modulating PI(4,5)P2 levels and the organization of apical Rab6-, Rab11-, and Rab30-dependent trafficking.

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