3,915 results found
    1. Developmental Biology
    2. Neuroscience

    Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

    Matthew P Bostock, Anadika R Prasad ... Vilaiwan M Fernandes
    Photoreceptors diversify their target field at long range through a graded signal.
    1. Developmental Biology

    Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    The homeodomain protein Bsh increases lamina neuron types and visual function.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Adult axolotls can regenerate original neuronal diversity in response to brain injury

    Ryoji Amamoto, Violeta Gisselle Lopez Huerta ... Paola Arlotta
    Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long-distance circuitry and tissue architecture.
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino, Erin Clark ... Sacha B Nelson
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.
    1. Neuroscience

    Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

    Saša Jereb, Hun-Way Hwang ... Robert B Darnell
    Differential expression of 3'UTR isoforms expands regulatory and protein diversity in cerebellar Purkinje and granule cells and during granule cell development.
    1. Neuroscience

    Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

    Mubarak Hussain Syed, Brandon Mark, Chris Q Doe
    A steroid hormone acts directly on brain neural progenitors to coordinately alter gene expression and specify neuronal and glial cell types.
    1. Neuroscience

    The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

    Hui Zhang, Haifang Wang ... Jie He
    Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.
    1. Developmental Biology
    2. Neuroscience

    Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit

    Maggie M Shin, Catarina Catela, Jeremy Dasen
    Genetic and anatomical analyses of Hox gene function uncover a limb-independent program of sensory neuron fate specification and connectivity.
    1. Neuroscience

    Direct extraction of signal and noise correlations from two-photon calcium imaging of ensemble neuronal activity

    Anuththara Rupasinghe, Nikolas Francis ... Behtash Babadi
    An inference paradigm for extracting neuronal correlations from two-photon imaging data, without requiring intermediate spike deconvolution, provides significant performance gains over existing methods as demonstrated by theoretical analysis, simulation studies, and real-data applications.

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