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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira, Nicholas MI Taylor ... Henning Stahlberg
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Neuroscience

    Independent representations of ipsilateral and contralateral limbs in primary motor cortex

    Ethan A Heming, Kevin P Cross ... Stephen H Scott
    Neural recordings demonstrate how information about the contralateral limb can be isolated from the ipsilateral limb in motor cortex.
    1. Neuroscience

    Multiple objects evoke fluctuating responses in several regions of the visual pathway

    Meredith N Schmehl, Valeria C Caruso ... Jennifer M Groh
    Neural fluctuations in multiple areas along the visual cortical hierarchy could allow the brain to represent distinct co-occurring visual stimuli.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

    Grégory Verdon, SeCheol Oh ... Olga Boudker
    Crystal structures of an archaeal homologue of mammalian glutamate transporters in apo and ion-only bound outward- and inward-facing states reveal ion-coupled conformational changes supporting mechanisms of coupling, gating, and transport.
    1. Developmental Biology

    Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining

    Wentao Yu, Lei Kang ... Terence TW Wong
    TRUST, as a rapid and fully automated whole-organ imaging technique, enables high-resolution multicolor 3D imaging at low cost by using a UV-LED for widefield illumination and a color camera while relieving researchers from lengthy and laborious tissue processing protocols.
    1. Neuroscience

    Uncertainty leads to persistent effects on reach representations in dorsal premotor cortex

    Brian M Dekleva, Pavan Ramkumar ... Lee E Miller
    When Rhesus monkeys plan reaching movements of which they are not fully confident, a particular area of the brain represents both the chosen action as well as alternate movements, perhaps as an aid for error correction or learning.
    1. Medicine
    2. Neuroscience

    Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

    Jörn Lötsch, Khayal Gasimli ... Marco Sisignano
    Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
    1. Microbiology and Infectious Disease

    RETRACTED: Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer

    Yang Li, Kai-Xuan Li ... Jie Yan
    L. interrogans utilizes endocytic recycling and vesicular transport systems for transcytosis across endothelial or epithelial barrier in blood vessels or renal tubules, which contributes to spreading and transmission of leptospirosis.
    1. Neuroscience

    Sensitivity to visual features in inattentional blindness

    Makaela Nartker, Chaz Firestone ... Ian Phillips
    Revised
    Reviewed Preprint v2
    Updated
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    1. Neuroscience

    Globus pallidus dynamics reveal covert strategies for behavioral inhibition

    Bon-Mi Gu, Robert Schmidt, Joshua D Berke
    Rats can pre-position the state of their basal ganglia neural networks to adaptively influence their subsequent response to a Go signal.