Leanne M Holt, Raymundo D Hernandez ... Michelle L Olsen
Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
Two alternative models of PKA activation were tested in neurons, and the results support the classical model in which the catalytic subunit dissociated from the regulatory subunit upon activation.
William F Podlaski, Alexander Seeholzer ... Tim P Vogels
The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.
Nicholas C Vierra, Michael Kirmiz ... James S Trimmer
A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
William T Redman, Nora S Wolcott ... Michael J Goard
Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
Francisco J Herrera, Teppei Yamaguchi ... Robert Tjian
An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
Salvador Dura-Bernal, Benjamin A Suter ... William W Lytton
The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.