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A model of early postnatal bacterial meningitis in the mouse demonstrates the transcriptome responses of each of the major meningeal cell types and should prove useful in dissecting the pathophysiology of bacterial meningitis in human infants.

P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.

A neural precursor cell defect precedes widespread inflammation, amyloid plaque pathology, and cognitive deficit in Alzheimer's disease, which can be reversed by inhibiting USP16.

Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.

The dorsal telencephalon (pallium) in medaka fish accommodates an epigenetically distinct brain area that selectively regulates unique set of synaptic genes compared to the surrounding pallial region, providing insights into the evolution of the pallium in vertebrate.

A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.

Lysosomal clustering around the microtubule-organizing centre would be a promising therapeutic strategy for Parkinson's disease.

Caenorhabditis elegans egg-laying behaviour shows pronounced variation in natural populations, making it a promising model to investigate the microevolution of a simple neural circuit.

Together, our multi-tissue single-cell data shows that CD56^bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.

Iodixanol supplementation provides a simple method for tuning the refractive index of live imaging media, which can greatly improve resolution and penetration depth in live imaging experiments.