Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
The transcription factor Pou3f1 triggers embryonic stem cells to become neuronal progenitor cells in two ways: by activating the expression of pro-neuronal genes and by blocking external inhibitory signaling cascades.
Comprehensive, high-resolution lineage mapping of the fly brain reveals straightforward rules that drive neuronal complexity and probable evidence of brain evolution.
Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.
A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
Large-scale changes in the brain's functional circuitry can be brought about by simple changes in gene expression in neural stem cells during development.
Mapping individual neural stem cells to their corresponding embryonic and postembryonic progeny shows that these sets of neurons have profound molecular and anatomical similarities despite building different central nervous systems.