1,210 results found
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV et al.
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Developmental Biology

    The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

    Qingqing Zhu et al.
    The transcription factor Pou3f1 triggers embryonic stem cells to become neuronal progenitor cells in two ways: by activating the expression of pro-neuronal genes and by blocking external inhibitory signaling cascades.
    1. Developmental Biology

    Conservation and divergence of related neuronal lineages in the Drosophila central brain

    Ying-Jou Lee et al.
    Comprehensive, high-resolution lineage mapping of the fly brain reveals straightforward rules that drive neuronal complexity and probable evidence of brain evolution.
    1. Developmental Biology
    2. Neuroscience

    A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

    Brandon Mark et al.
    Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.
    1. Developmental Biology
    2. Neuroscience

    Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS

    Haluk Lacin et al.
    Unc-4 acts in a lineage-specific manner to promote different neuronal fates and locomotion behavior in Drosophila.
    1. Developmental Biology
    2. Neuroscience

    Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex

    Cathryn R Cadwell et al.
    Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Developmental Biology
    2. Neuroscience

    Genetic transformation of structural and functional circuitry rewires the Drosophila brain

    Sonia Sen et al.
    Large-scale changes in the brain's functional circuitry can be brought about by simple changes in gene expression in neural stem cells during development.
    1. Developmental Biology
    2. Neuroscience

    Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system

    Haluk Lacin, James W Truman
    Mapping individual neural stem cells to their corresponding embryonic and postembryonic progeny shows that these sets of neurons have profound molecular and anatomical similarities despite building different central nervous systems.

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