2,404 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki, Ali Sarkeshik ... Paul Schedl
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

    Jiajie Diao, Patricia Grob ... Axel T Brunger
    A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
    1. Structural Biology and Molecular Biophysics

    Myosin motors fragment and compact membrane-bound actin filaments

    Sven K Vogel, Zdenek Petrasek ... Petra Schwille
    A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom, Chaolin Zhang ... Robert B Darnell
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Developmental Biology
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen, Marta Koch ... Bassem A Hassan
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li, Kevin M Collins ... Kang Shen
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Neuroscience

    Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

    Elizabeth D Kirby, Sandra E Muroy ... Daniela Kaufer
    Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.
    1. Cell Biology
    2. Developmental Biology

    Ovulation in Drosophila is controlled by secretory cells of the female reproductive tract

    Jianjun Sun, Allan C Spradling
    Secretory cells in the fruit fly reproductive tract produce secretions that control ovulation through a conserved mechanism that could provide insights into ovarian cancer.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

    Jiajie Diao, Jacqueline Burré ... Axel T Brunger
    Experiments on synthetic models of synaptic vesicles have shed new light on the role of the protein α-synuclein in the central nervous system.

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