Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.

The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.

Dynamic SILAC labeling in combination with mass spectrometry revealed substantial regulation of protein synthesis, degradation, turnover, and abundance during homeostatic scaling in neurons.

Cohesin is required for the expression of neuronal genes that engage in long chromatin loops, while short-range enhancer-promoter loops can form in the absence of cohesin.

The eIF3 translation initiation complex exerts specific regulation on neuronal protein levels by targeting mRNAs with GC-rich 5' UTR.

PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.

A new Cereblon-recruiting bifunctional tau ligand, QC-01-175, promotes aberrant tau degradation and rescue of stress vulnerability in human neuronal cell models of tauopathy.

NSF is part of a membrane trafficking quality control system that disassembles both properly formed and off-pathway SNARE complexes, and the disassembly activity may be regulated by complexin.

Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.

The processing of light and dark contrast information for detecting impending visual threats within grasshopper neurons reveals new mechanisms of information processing in the brain.