2,298 results found
    1. Neuroscience

    Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila

    Ugur Dag et al.
    Consolidation of long-term courtship memory in Drosophila is mediated by a novel class of sleep promoting neurons that reactivates dopaminergic neurons engaged earlier in memory acquisition during post-learning sleep.
    1. Developmental Biology

    A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

    Christie Ciarlo et al.
    Akt activation is required for neural crest differentiation through regulation of Sox10 activity.
    1. Neuroscience

    Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

    Patrícia A Correia et al.
    Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
    1. Neuroscience

    Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

    Pierre-Yves Musso et al.
    The Sip-Triggered Optogenetic Behavior Enclosure (STROBE) produces robust behaviors via activation of peripheral or central neurons in the fly, and mimics key features of feeding driven by chemical taste ligands.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels

    Weiwei Wang et al.
    Determining how GIRK2 activity depends on the concentration of Gβγ subunits in lipid membranes at different Na+ concentrations has allowed the Gβγ concentration generated during GABAB activation in neurons to be estimated.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

    Ivan Kadurin et al.
    Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.
    1. Neuroscience

    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

    Ambra Masuzzo et al.
    The universal bacteria cell wall component peptidoglycan impacts the egg-laying behavior of infected Drosophila females by directly modulating the activity of few brain octopaminergic neurons.
    1. Neuroscience

    VTA neurons coordinate with the hippocampal reactivation of spatial experience

    Stephen N Gomperts et al.
    During quiet wakefulness but not slow wave sleep, reward modulated VTA neurons coordinate selectively with hippocampal replay sequences and are biased in their timing towards the reactivated representation of reward locations.
    1. Neuroscience

    Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

    Elizabeth D Kirby et al.
    Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.

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