Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
Francisco J Herrera, Teppei Yamaguchi ... Robert Tjian
An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
Anthony J Linares, Chia-Ho Lin ... Douglas L Black
The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.
Neale J Harrison, Elizabeth Connolly ... Alicia Hidalgo
Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.
Jürgen Tuvikene, Eli-Eelika Esvald ... Tõnis Timmusk
An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
Characterization of a novel population of enteric nervous system glial cells in zebrafish reveals their proliferative and neurogenic properties under homeostatic conditions in adults, properties difficult to model in mammals.
