281 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
    1. Cancer Biology
    2. Developmental Biology

    Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

    Karine Narbonne-Reveau et al.
    Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.
    1. Developmental Biology

    Mamo decodes hierarchical temporal gradients into terminal neuronal fate

    Ling-Yu Liu et al.
    Neuronal diversity is expanded by a temporal fating paradigm utilizing hierarchical gene regulation.
    1. Developmental Biology
    2. Neuroscience

    How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits

    Julia L Meng et al.
    In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.
    1. Developmental Biology
    2. Neuroscience

    The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

    Merve Deniz Abdusselamoglu et al.
    Odd-paired (opa) is required for the progression of temporal patterning in Drosophila neural progenitors to regulate temporal identities via an incoherent feed-forward loop.
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Developmental Biology
    2. Neuroscience

    Developmental Neuroscience: Re-utilization of a transcription factor

    Filipe Pinto-Teixeira, Claude Desplan
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    1. Neuroscience

    Neuroscience: How to train a neuron

    Rui P Costa et al.
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    1. Developmental Biology
    2. Neuroscience

    Neurotransmitter Identity: A question of lineage

    Sonia Sen
    In the ventral nerve cord of fruit flies, neurons from the same hemilineage use the same neurotransmitter.
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    1. Developmental Biology
    2. Neuroscience

    Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification

    Esteban Hoijman et al.
    Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.

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