Context-dependent optimization of Gli-binding site occupancy, in the presence of Hand2, is critical for modulating tissue-specific transcriptional output within tissues that lack an obvious Hedgehog morphogen gradient.
Human perceptual sensitivity to frequency modulation across the hearing range can be explained by a unitary neural code based on neural responses to amplitude modulation and fidelity of cochlear tuning.
Administration of dopamine and opioid receptor antagonists resulted in reduced reward anticipation (effort and increased negative facial reactions), but only administration of opioid antagonists resulted in reduced liking (facial reactions).
An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.
A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.