112 results found
    1. Neuroscience

    Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

    Stéphanie Ratté et al.
    No single molecular change is uniquely necessary to cause neuropathic changes in primary afferent excitability; multiple different changes are sufficient.
  1. Fabry Disease: Ion channels and neuropathic pain

    Madeleine C Klein, Anne Louise Oaklander
    Pain behaviors in a Fabry mouse model are associated with the accumulation of a fat molecule that disrupts sodium ion channels in small fiber neurons.
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    1. Neuroscience

    Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

    Margarita Calvo et al.
    Type 1 potassium channels alter their composition and localisation to suppress hyper-excitability and neuropathic pain of injured sensory neurons.
    1. Neuroscience

    Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

    Josette J Wlaschin et al.
    The DLK response pathway in neurons initiates the cascade of events leading to neuropathic pain after injury.
    1. Neuroscience

    Neuropathic Pain: The pros and cons of degeneracy

    Jean-Marc Goaillard, Martial A Dufour
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    1. Cancer Biology
    2. Neuroscience

    Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

    Peter M LoCoco et al.
    Stimulation of the rate-limiting enzyme in the NAD salvage pathway protected against neurotoxicity and subsequent peripheral neuropathy associated with the widely utilized anticancer drug, paclitaxel.
    1. Neuroscience

    Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage

    Jennifer Resnik, Daniel B Polley
    Dynamic regulation of feedforward inhibition from parvalbumin-expressing inhibitory neurons is linked to the gradual restoration of cortical sensory processing following auditory nerve damage.
    1. Neuroscience

    Animal Models of Disease: Fly model causes neurological rethink

    Madhumala K Sadanandappa, Mani Ramaswami
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Neuropathy: Looking into nerve damage in the cornea

    Mihaela Gadjeva
    Interactions between T helper cells and the complement system promote loss of sensory neurons in the eye.
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    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Thalidomide: Unlocking a dark past

    Fernando Rodríguez-Pérez, Michael Rape
    A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
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