191 results found
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet et al.
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek et al.
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Biochemistry and Chemical Biology

    Chaperones: Aggregation in the spotlight

    Zihao Wang et al.
    New findings clarify apparently conflicting results about how molecular agents that preserve protein integrity prevent harmful, dense aggregates from forming.
    Insight
    Available as:
    • HTML
    • PDF
    1. Cell Biology

    Endoplasmic reticulum tubules limit the size of misfolded protein condensates

    Smriti Parashar et al.
    The endoplasmic reticulum (ER) uses ER tubules and specific ER autophagy machinery to prevent toxic, dominant-interfering, disease-causing, mutant proteins from entering the secretory pathway.
    1. Neuroscience

    Learning to stand with unexpected sensorimotor delays

    Brandon G Rasman et al.
    The nervous system can learn to control standing balance with added sensorimotor delays by causally linking delayed whole-body sensory feedback, initially deemed as unexpected, to self-generated balance motor commands.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

    Jessica P Kuppan et al.
    Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.
    1. Neuroscience

    Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

    Oshri Avraham et al.
    The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes et al.
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Medicine
    2. Neuroscience

    Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

    Xiao Lv et al.
    PGE2/EP4 skeleton interoception regulates bone and fat metabolism via hypothalamic NPY.

Refine your results by:

Type
Research categories