121 results found
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Neuroscience

    Shared and specific signatures of locomotor ataxia in mutant mice

    Ana S Machado et al.
    LocoMouse analysis of severely ataxic reeler mutant mice reveals fundamental features of locomotor ataxia and provides a roadmap for linking high-dimensional behavioral phenotyping to alterations in underlying neural circuits.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    The sheddase ADAM10 is a potent modulator of prion disease

    Hermann C Altmeppen et al.
    A lack of ADAM10-mediated shedding increases prion protein levels at the plasma membrane and promotes the generation of pathological prion proteins, which accelerates prion disease in mice.
    1. Neuroscience

    TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

    Maxime WC Rousseaux et al.
    Convergent screens targeting the levels of alpha-synuclein and tau identify TRIM28 as a driver of their stability, nuclear accumulation and subsequent toxicity.
    1. Developmental Biology
    2. Immunology and Inflammation

    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

    Katrin Kierdorf et al.
    A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.
    1. Neuroscience

    Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

    Julia Patzig et al.
    A newly identified component in the architecture of the axon/myelin-unit – the septin/anillin scaffold – maintains the structure of myelin in the central nervous system, thereby preventing myelin outfoldings.
    1. Neuroscience

    Translational control of auditory imprinting and structural plasticity by eIF2α

    Gervasio Batista et al.
    Behavioral pharmacology and molecular biology reveal a translational control mechanism underlying auditory imprinting and structural plasticity that can be pharmacologically manipulated to reopen the critical period.
    1. Medicine
    2. Neuroscience

    APOE2 is associated with longevity independent of Alzheimer’s disease

    Mitsuru Shinohara et al.
    Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
    1. Developmental Biology
    2. Neuroscience
    Pond snail illustration

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor et al.
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Neuroscience

    Mating Behaviour: To mate or not to mate

    Florencia Campetella, Silke Sachse
    Insight
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