FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
Hippocampal and prefrontal neuronal populations form slow behavioral-timescale (~seconds) and fast cognitive-timescale (~100 ms) sequential activity patterns as theta and replay sequences, which play distinct yet cooperative roles in memory-guided decision-making.
Analysis of human fMRI data reveal that intermediary areas within the fronto-parietal control network (FPCN) are critical for integrating control processing, cognitive ability, and amenability to neuromodulation.
Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.