138 results found
    1. Neuroscience

    Neural signatures of auditory hypersensitivity following acoustic trauma

    Matthew McGill, Ariel E Hight ... Daniel B Polley
    Chronic two-photon calcium imaging, optogenetics, and operant behavioral approaches were leveraged to show that hyperactivity, hyperresponsivity, and hypersynchronization in auditory cortex neural ensembles can account for auditory hypersensitivity following acoustic trauma.
    1. Neuroscience
    2. Medicine

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis, Pablo Martínez-Cañada ... Michael V Lombardo
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Neuroscience

    Change point estimation by the mouse medial frontal cortex during probabilistic reward learning

    Cayla E Murphy, Hongli Wang ... Huriye Atilgan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Inadequate
    1. Neuroscience

    Interneuron-specific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex

    Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo Womelsdorf
    A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.
    1. Epidemiology and Global Health

    Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

    Marina Padilha, Victor Nahuel Keller ... Gilberto Kac
    A panel of serum biomarkers, including dietary and microbial-derived metabolites related to the gut-brain axis, were identified as potential for tracking children at risk of early childhood developmental delays.
    1. Neuroscience

    Making memories last using the peripheral effect of direct current stimulation

    Alison M Luckey, Lauren S McLeod ... Sven Vanneste
    Non-invasive transcutaneous electrical stimulation of the greater occipital nerve using direct current promotes strengthening of memories using late-phase synaptic activity.
    1. Neuroscience

    Computational mechanisms of curiosity and goal-directed exploration

    Philipp Schwartenbeck, Johannes Passecker ... Karl J Friston
    Distinct computational levels of uncertainty compel agents to gain information about hidden states in the world (‘active inference’) or optimise their ‘world model’ as such (‘active learning’).
    1. Neuroscience

    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

    Flavio H Beraldo, Daniel Palmer ... Marco AM Prado
    Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.
    1. Neuroscience

    Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection

    Murat Kilinc, Vineet Arora ... Gavin Rumbaugh
    Alternatively spliced C-terminal protein sequences encoded by the Syngap1 gene exhibit unique biochemical and functional properties in vivo, which explain in part how individual isoforms can promote cognitive functions and seizure protection.
    1. Neuroscience

    Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

    Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins
    Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.

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