8 results found
    1. Genetics and Genomics

    mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

    Fivos Borbolis et al.
    mRNA decapping function in neuronal cells regulates neurosecretion and intertissue signaling, affecting developmental and ageing processes in two model organisms.
    1. Cell Biology
    2. Neuroscience

    Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

    Alexander M Walter et al.
    Increasing PI(4,5)P2 on a sub-second timescale using a novel, membrane-permeant UV activatable PI(4,5)P2 molecule augments exocytosis which requires the PI(4,5)P2 interacting exocytotic proteins Munc13-2 and synaptotagmin-1.
    1. Neuroscience

    Decoding a neural circuit controlling global animal state in C. elegans

    Patrick Laurent et al.
    Sensory neurons that monitor ambient oxygen control a cascade of responses across multiple layers of interneurons to switch the global state of the nematode C. elegans, reprogramming behavior and gene expression to enable escape from or adaptation to surface exposure.
    1. Neuroscience

    Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking

    Jamshid Faraji et al.
    Social enrichment supports longevity.
    1. Neuroscience

    Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain

    Elizabeth A Williams et al.
    A combination of electron microscopic reconstruction and the analysis of single cell transcriptome data is used to reconstruct synaptic and peptidergic signaling networks in a neurosecretory centre.
    1. Neuroscience

    Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

    Bassam Tawfik et al.
    Synaptotagmin-7 acts synergistically with synaptotagmin-1 by placing vesicles close to the plasma membrane within reach of the SNARE/Munc13-complex, supporting their priming and setting the stage for fast and slow fusion.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.

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