196 results found
    1. Neuroscience

    Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

    Rebekah Elizabeth Mahoney et al.
    By regulating protein translation within the neuron, insulin signaling can control neuronal activity by altering the release of neurotransmitter molecules.
    1. Neuroscience

    Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission

    Austin L Reese, Ege T Kavalali
    In a population of mammalian central synapses, spontaneous and evoked neurotransmitter release processes are independently distributed; yet, postsynaptic receptors within a single synapse preferentially receive neurotransmitter from only one mode of release.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

    Mattia Volta et al.
    LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
    1. Neuroscience

    Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans

    Sarah G Leinwand et al.
    Neurotransmission pathways from primary to secondary neurons encode odor and underlie age-related sensory behavioral declines.
    1. Neuroscience

    The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

    Yongchao Han et al.
    BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Neuroscience

    Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

    Austin L Reese, Ege T Kavalali
    Individual neurons can adjust the strength of their synapses by using spontaneous calcium influx through NMDA receptors to trigger the release of additional calcium from intracellular stores, which can in turn be used to regulate protein synthesis.
    1. Neuroscience

    Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

    Jian Qiu et al.
    Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.
    1. Neuroscience

    Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem

    Miae Jang et al.
    Oligodendrocytes are actively engaged in the precise control of synaptic functions in the CNS through activity-dependent BDNF signaling.
    1. Neuroscience

    An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

    Yu Shen et al.
    The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.

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