274 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker et al.
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Neuroscience

    Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy

    Enya Paschen et al.
    Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.
    1. Neuroscience

    Correlating STED and synchrotron XRF nano-imaging unveils cosegregation of metals and cytoskeleton proteins in dendrites

    Florelle Domart et al.
    The development of high-resolution correlative imaging of metals and proteins reveals the interaction of copper and zinc with the synaptic architecture of neurons.
    1. Genetics and Genomics
    2. Neuroscience

    Cell non-autonomous regulation of health and longevity

    Hillary A Miller et al.
    Modulation of the aging process through cell signaling represents a recent and exciting area of study with the potential for development of therapeutics to extend human health.
  1. Ion channels: A Collection of Articles

    Edited by Kenton J Swartz et al.
    eLife has published papers on topics related to the molecular structure and functional mechanisms of a diverse array of ion channel proteins.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Amol K Bhandage et al.
    Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.
    1. Structural Biology and Molecular Biophysics

    Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters

    Xiaoyu Wang, Olga Boudker
    Substrate releasing or inhibitor binding on the intracellular side of a glutamate transporter homologue require movements of the transport domain through the lipid membrane, which undergoes adaptive deformations.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

    Damien Lemoine et al.
    A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
    1. Neuroscience

    Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

    Tyler G Ekins et al.
    An excess of novel non-canonical subtypes of parvalbumin+ interneurons in a mouse model of classical lissencephaly, which possess non-fast-spiking physiological properties, may contribute to network hyperexcitability common in this model.
    1. Developmental Biology
    2. Neuroscience

    Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus

    Jessica E Biddinger et al.
    Leptin acts cell autonomously on brainstem neurons that express GLP-1 to suppress development of excitatory viscerosensory inputs to the hypothalamus.

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