BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.

Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.

TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.

Subtle differences in handling of intracellular cations can drive macroscopic functional differences in structurally similar monoamine transporters.

Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.

Potassium presumably binds to the Na1 site in LeuT, playing a role in inwardly rectifying the transport of substrates.

Glutamate transporter homologs can efficiently bind and transport both L- and D- enantiomeric substrates with only slight rearrangements in the binding site.

While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.

Expression pattern analysis of neurotransmitter synthesis, secretion, and reuptake machinery reveals animal-wide usage of neurotransmitters in both sexes of Caenorhabditis elegans.

The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.