480 results found
    1. Neuroscience

    The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

    Yongchao Han, Liangyao Xiong ... Tao Wang
    BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Cell Biology
    2. Neuroscience

    Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

    Yongchao Han, Lei Peng, Tao Wang
    TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Neuroscience

    The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Drew Stenesen, Andrew T Moehlman, Helmut Krämer
    Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
    1. Neuroscience

    Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

    Moritz Armbruster, Chris G Dulla, Jeffrey S Diamond
    Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

    Solveig G Schmidt, Andreas Nygaard ... Claus J Loland
    Potassium presumably binds to the Na1 site in LeuT, playing a role in inwardly rectifying the transport of substrates.
    1. Neuroscience

    Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

    Xiling Bian, Jiemin Zhu ... Yi Rao
    While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.
    1. Neuroscience

    Cerebral chemoarchitecture shares organizational traits with brain structure and function

    Benjamin Hänisch, Justine Y Hansen ... Sofie Louise Valk
    Dimensionality reduction techniques reveal how the organization of neurotransmitter receptor and transporter co-expression in the human brain may bridge the gap between brain structure and function.
    1. Neuroscience

    A neurotransmitter atlas of C. elegans males and hermaphrodites

    Chen Wang, Berta Vidal ... Oliver Hobert
    Expression pattern analysis of neurotransmitter synthesis, secretion, and reuptake machinery reveals animal-wide usage of neurotransmitters in both sexes of Caenorhabditis elegans.
    1. Structural Biology and Molecular Biophysics

    Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

    Shreyas Bhat, Marco Niello ... Walter Sandtner
    Subtle differences in handling of intracellular cations can drive macroscopic functional differences in structurally similar monoamine transporters.
    1. Medicine
    2. Neuroscience

    Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems

    Lisa Hahn, Simon B Eickhoff ... Matthias L Schroeter
    Local brain functional activity reductions in bvFTD follow the distribution of serotonergic, GABAergic, and norepinephrinergic neurotransmitter systems, indicating a selective vulnerability and providing novel insights into the underlying disease mechanisms.

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