Browse the search results

Page 2 of 42
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions

    Wenxuan Liu et al.
    Skeletal muscle stem cells play important roles in the regeneration of neuromuscular junctions, and so present new targets for therapies to treat neuromuscular decline observed in the context of aging and various neuromuscular diseases.
    1. Developmental Biology

    Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis

    Shauna L Houlihan et al.
    Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore et al.
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al.
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Cell Biology
    2. Neuroscience

    Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

    Guanglin Xing et al.
    Neurexin–Neuroligin1 complex positively regulates F-actin assembly through direct interaction with WAVE complex to control normal synaptic growth and electrophysiological function in Drosophila neuromuscular junction.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
    1. Cell Biology
    2. Developmental Biology

    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

    Alireza Ghasemizadeh et al.
    Maintenance of peripheral myonuclei patterning in skeletal myofibers is dependent on the regulation of microtubules dynamic and nuclei motion and is essential for proper neuromuscular junction integrity and mitochondria homeostasis.
    1. Cell Biology
    2. Neuroscience

    Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity

    James Ashley et al.
    Synaptic partner recognition in the Drosophila neuromuscular circuit requires interactions between the Dpr and DIP subfamilies of immunoglobulin cell-surface proteins.
    1. Neuroscience

    A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

    Guanglin Xing et al.
    Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of Rapsyn, impairs the neuromuscular junction by disrupting agrin signaling.
    1. Developmental Biology
    2. Neuroscience

    How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits

    Julia L Meng et al.
    In vivo stem cell reprogramming in the well-studied stem cell NB7-1 using the classic temporal transcription factor Hunchback increases motor neuron number and re-specifies dendritic morphology and neuromuscular synaptic partnerships.