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Structural Biology and Molecular Biophysics
Gastrulation: May the force be with you
Shinuo Weng, John B Wallingford
Understanding the coordination of the forces generated in embryos by two processes, convergent extension and convergent thickening, is key to understanding how a hollow sphere of cells develops into an elongated embryo.
Addressing the ethical issues raised by synthetic human entities with embryo-like features
John Aach et al.
Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate
Ilya Chuykin et al.
Par3 is polarized in the plane of the vertebrate neural plate, binds and recruits Prickle3 to the apical membrane and promotes the formation of core planar cell polarity complexes.
Wnt proteins can direct planar cell polarity in vertebrate ectoderm
Chih-Wen Chu, Sergei Y Sokol
Vertebrate early ectoderm displays planar polarity manifested by a fluorescent sensor and this polarity can be instructed by Wnt ligands.
Proliferation-independent regulation of organ size by Fgf/Notch signaling
Agnė Kozlovskaja-Gumbrienė et al.
Cell adhesion regulates organ size in the zebrafish lateral line system.
Mutations associated with human neural tube defects display disrupted planar cell polarity in
Ashley C Humphries et al.
Human neural tube closure defects associated mutations in planar cell polarity (PCP) genes are causative of the disease, as revealed in the intricate
Genetics and Genomics
celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish
Chunmei Li et al.
The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior
Alexandre Alié et al.
A comparative approach shows that developmental evolution of neuropeptidergic neuronal groups in the hypothalamus of blind cavefish drives adaptive behavioral evolution.
Maternally regulated gastrulation as a source of variation contributing to cavefish forebrain evolution
Jorge Torres-Paz et al.
Phenotypic evolution can originate from variations in very precocious developmental events, starting even before fecundation, during the fabrication of the egg in the mother's gonad.
Physics of Living Systems
Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation
Robert J Huebner et al.
Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
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