533 results found
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

    Julie Y Zhou et al.
    Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.
    1. Cell Biology
    2. Evolutionary Biology

    A flagellate-to-amoeboid switch in the closest living relatives of animals

    Thibaut Brunet et al.
    The closest living relatives of animals, the choanoflagellates, switch from a flagellate to an amoeboid phenotype under confinement.
    1. Immunology and Inflammation
    2. Medicine

    Perinatal granulopoiesis and risk of pediatric asthma

    Benjamin A Turturice et al.
    Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme et al.
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Neuroscience

    Transsynaptic mapping of Drosophila mushroom body output neurons

    Kristin M Scaplen et al.
    Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.
    1. Immunology and Inflammation

    Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells

    Dong Hyun Kim et al.
    Cellular immunological and biochemical analyses reveal how decoy IL-1RII is induced by human CD4+ T cells upon TCR-stimulation and regulates the Th17-Treg balance by modulating IL-1β responsiveness in IL-1RI+ cells.
    1. Evolutionary Biology
    2. Neuroscience

    Shore crabs reveal novel evolutionary attributes of the mushroom body

    Nicholas Strausfeld, Marcel E Sayre
    Dramatic phenotypic divergence of crustacean mushroom bodies map to phylogenetic lineages, thereby offering unexplored opportunities for relating divergent cognitive centers to different ecologies and behavioral repertoires required to negotiate them.
    1. Neuroscience

    Spatial modulation of visual responses arises in cortex with active navigation

    E Mika Diamanti et al.
    Spatial modulation along the visual pathway arises in the cortex and strengthens with active navigation and experience.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Properdin oligomers adopt rigid extended conformations supporting function

    Dennis V Pedersen et al.
    Combining electron microscopy and solution scattering demonstrated that properdin oligomers adopt extended rigid and well-defined conformations that are integral to the biological function of this complement regulator.
    1. Immunology and Inflammation

    Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

    Bruce Zhang, David Gems
    The absence of helminth parasites in developed countries may be exacerbating pathological, age-associated inflammation, known as inflammaging, suggesting that helminth therapies could provide protection against age-related disease.

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