385 results found
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu et al.
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda et al.
    Tumor stiffness blocks T cell migration in tumors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

    Ilhame Diboun et al.
    PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.
    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen et al.
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
    1. Medicine

    Development and validation of a nomogram to better predict hypertension based on a 10-year retrospective cohort study in China

    Xinna Deng et al.
    A developed and validated nomogram better predicts the risk of hypertension based on a 10-year retrospective cohort study in China.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

    Tania Lebratti et al.
    Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.
    1. Neuroscience

    Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

    Jonas Hansen Kymre et al.
    Electrophysiological and morphological identification of individual pheromone projection neurons in male moth reveals a coding system for optimizing mate search strategy, including computation of three female-produced signals in distinct protocerebral regions.
    1. Immunology and Inflammation

    Perinatal development of innate immune topology

    Philipp Henneke et al.
    At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.

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