The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.

Biochemical and instrumental analysis showed that the membrane-induced exposure of myristoyl from the MA protein of Mason-Pfizer monkey virus triggers allosteric conformational changes resulting in MA oligomerization and unfolding of the cleavage site between MA and downstream domains of Gag.

An unprecedented large-scale screen in mice for morphogenetic regulators of tissue development provides major new insights into the roles of Rho GTPases in diverse array of skin developmental processes.

Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.

Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.

A general framework captures the evolutionary routes leading to the formation and progression of tumors.

Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.

COV-ID is a highly scalable technology that utilizes a two-step barcoding strategy to detect viral RNAs in saliva samples combining RT-LAMP, PCR, and next generation sequencing.