321 results found
    1. Genetics and Genomics
    2. Neuroscience

    Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation

    Martina Rudgalvyte, Zehan Hu ... Dominique A Glauser
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Cancer Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Neuroscience

    Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

    Jiayao Zhang, Juan Li ... Weicai Liu
    miR-335-3p, which targets FOS and inhibits its activation of NFATC1 signaling, is an important regulator for osteoclast function and responsible for the psychological stress-induced osteoporosis.
    1. Genetics and Genomics

    DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

    Hilda Tateossian, Amy Southern ... Steve DM Brown
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

    Paolo Petazzi, Telma Ventura ... Antonella Fidanza
    A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
    1. Cell Biology
    2. Medicine

    Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway

    Yongli Qin, Jumpei Shirakawa ... Baohong Zhao
    Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration, establishing a novel paradigm in tissue homeostasis and repair.
    1. Cell Biology

    Inclusive, exclusive and hierarchical atlas of NFATc1+/PDGFR-α+ cells in dental and periodontal mesenchyme

    Xue Yang, Chuyi Han ... Fanyuan Yu
    The inclusive, exclusive, and hierarchical atlas of NFATc1+/PDGFR-α+ cells in dental and periodontal mesenchyme is described.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

    Nelson V Simwela, Eleni Jaecklein ... David G Russell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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