316 results found
    1. Developmental Biology
    2. Neuroscience

    Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS

    Haluk Lacin et al.
    Lineally related neurons in the adult Drosophila ventral nerve cord use the same neurotransmitter to communicate with other neurons.
    1. Developmental Biology
    2. Neuroscience

    Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS

    Haluk Lacin et al.
    Unc-4 acts in a lineage-specific manner to promote different neuronal fates and locomotion behavior in Drosophila.
    1. Developmental Biology
    2. Neuroscience

    Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system

    Haluk Lacin, James W Truman
    Mapping individual neural stem cells to their corresponding embryonic and postembryonic progeny shows that these sets of neurons have profound molecular and anatomical similarities despite building different central nervous systems.
    1. Cell Biology
    2. Developmental Biology

    NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans

    Shaohe Wang et al.
    The C. elegans ninein homolog NOCA-1 is important for the assembly of non-centrosomal microtubule arrays required for embryo production, nuclear positioning and larval development.
    1. Cell Biology
    2. Genetics and Genomics

    Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

    David W Morgens et al.
    Using a suite of CRISPR technologies, unique chemical tools, and carefully designed biochemical and cell biological assays, we define the mechanism of action of Retro-2, an inhibitor of retrograde toxins.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

    Nalin Leelatian et al.
    A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
    1. Cancer Biology
    2. Cell Biology

    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

    Nitin H Shirole et al.
    Genetic and molecular analysis of TP53 exon-6 truncating mutations reveal that these mutations, contrary to current belief, promote tumorigenesis and point towards strategies for treating cancers driven by these prevalent mutations.
    1. Ecology

    Increasing plant diversity with border crops reduces insecticide use and increases crop yield in urban agriculture

    Nian-Feng Wan et al.
    Plant diversification can make an important contribution to ecological intensification and the sustainable use of associated ecosystem services in an urban ecosystem.

Refine your results by:

Type
Research categories