199 results found
    1. Neuroscience

    Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

    Dagmara Korona, Benedict Dirnberger ... Kathryn S Lilley
    Blocking of the function of neurotransmitter receptors by insecticidal peptide toxins resulted in identification of nicotinic acetylcholine receptor subunits through native ligand-binding investigations.
    1. Neuroscience

    Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

    Romain Durand-de Cuttoli, Sarah Mondoloni ... Alexandre Mourot
    In vivo deconstruction of reward-related behaviors with circuit and pharmacological specificity using designer, light-controllable nicotinic acetylcholine receptors.
    1. Structural Biology and Molecular Biophysics

    Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

    Steven De Gieter, Casey I Gallagher ... Rouslan G Efremov
    Cryo-EM structures of Cys-loop receptor Alpo4 from the thermophilic worm Alvinella pompejana show that a sterol derivative CHAPS binds in and outside of its orthosteric binding site and induces a quaternary twist.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella, Valentina Mastrorilli ... Marilena Griguoli
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Developmental Biology
    2. Neuroscience

    A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats

    Melody C Iacino, Taylor A Stowe ... Mark J Ferris
    A circuit within the nucleus accumbens that exists during a specific developmental window through early adolescence male rats may serve as a substrate that underlies heightened reward seeking in this population.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications

    Kaori Noridomi, Go Watanabe ... Lin Chen
    Autoantibodies from myasthenia gravis patients bind a common core region on the nicotinic acetylcholine receptor through a largely conserved mechanism.
    1. Neuroscience

    Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'

    James Taniguchi, Riccardo Melani ... Nicolas X Tritsch
    We are writing to comment on the article by Mohebi et al., 2023: we show that blue light alters the fluorescent properties of a genetically-encoded dopamine sensor in a manner that may be misconstrued as phasic dopamine release.
    1. Neuroscience

    An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

    Silke Frahm, Beatriz Antolin-Fontes ... Ines Ibañez-Tallon
    Local elimination of acetylcholine synthesis in habenular neurons demonstrates a key role for vesicular synergy and neurotransmitter co-release in nicotine dependence.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

    Anitha P Govind, Okunola Jeyifous ... William N Green
    Neuronal activity triggers the dispersal of the Golgi into dendritic Golgi satellites, leading to reshaping of the neuronal surface glycoproteome through processing of glycans to mature, sialic acid-containing forms.

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