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    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

    Saumel Ahmadi, Sunny Xia ... Christine E Bear
    Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.
    1. Neuroscience

    Glutamate is required for depression but not potentiation of long-term presynaptic function

    Zahid Padamsey, Rudi Tong, Nigel Emptage
    Electrophysiological and optical analysis of neurotransmitter release at central synapses reveals that glutamate signalling is not required for the long-term potentiation (LTP) of presynaptic function, and instead only promotes presynaptic long-term depression (LTD).
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca, Gautham Venugopalan ... Daniel A Fletcher
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Microbiology and Infectious Disease

    Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection

    John A Buglino, Gaurav D Sankhe ... Michael S Glickman
    M. tuberculosis, the bacterium that causes the disease tuberculosis, uses a signaling system that senses multiple products of the host's immune system to modify gene expression to colonize the lung.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin, Eleanor Johns ... Richard M White
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cancer Biology
    2. Cell Biology

    Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

    Saori Furuta, Gang Ren ... Mina J Bissell
    Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.
    1. Biochemistry and Chemical Biology

    Enzyme Mechanisms: Wedging open a catalytic site

    Annie Beuve
    The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.
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    1. Developmental Biology

    Visually induced changes in cytokine production in the chick choroid

    Jody A Summers, Elizabeth Martinez
    IL-6 gene and protein expression are rapidly and transiently upregulated in the choroid in response to myopic defocus, as a result of prior form deprivation or treatment with +15 D lenses in a nitric oxide-dependent manner.
    1. Neuroscience

    Neural Circuits: Avoiding UV light

    Maria Sachkova, Vengamanaidu Modepalli
    The larvae of an annelid worm use nitric oxide signalling to activate the neural pathways needed to swim away from the harmful ultraviolet light of the sun.
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    1. Ecology
    2. Evolutionary Biology

    Ecology: Keeping it fresh

    Jonathan L Klassen
    Beewolf wasp eggs release nitrogen oxides to provide protection against fungi and other microbes.
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