A new pathway is described involving the estrogen receptor alpha in the acute response of small arteries to flow independent of the ligand (estrogen) and of the nuclear signaling.
Seizures stimulate estrogen synthesis in the brain and acutely inhibiting brain estrogen synthesis suppresses seizures, in both sexes, without additional interventions.
Sean W Fanning, Christopher G Mayne ... Geoffrey L Greene
Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
James D Joseph, Beatrice Darimont ... Jeffrey H Hager
GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
A deep-sea Planctomycetes bacterium performs a unique budding mode of division and recruits chronic phages for metabolizing nitrogen through the function of auxiliary metabolic genes.
17α-Estradiol, a life-span extending compound, signals through estrogen receptor α (ERα) in the liver and hypothalamus to elicit health benefits in a sex-specific manner.
Driving melanoma differentiation through G protein-coupled estrogen receptor signaling decreases proliferative capacity, decreases expression of the oncodriver and stem cell marker c-Myc, and increases the effectiveness of immunotherapy.
Sufficient aspartate drives specialization within a microbial colony, when some cells use it to create a limited carbon-resource, while other cells consume this resource and use aspartate for nucleotide synthesis.
